Effect of protein restriction on the progression of diabetic nephropathy. A prospective 30-month follow-up study.:A Prospective 30-Month Follow-up Study
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The effect of protein restriction on the clinical course of diabetic nephropathy was investigated in a prospective study.<BR>Eleven non-insulin-dependent diabetic patients with diabetic nephropathy were allocated to this study. Patients were divided into two groups: group 1, a protein-restrictedgroup {n=5, protein (0.8-1.0g/kg standard body weight)}; group 2, a protein-unrestricted group {n=6, protein 70-90g/day or 1.2-1.5g/kg standard body weight}. There were no significant differences between the two groups in age, known duration of DM, FBS, HbA<SUB>1</SUB>c, or blood pressure at the beginning of the prospective follow-up study.<BR>During the 30-month follow-up period, there were no significant differences in the degree of control of blood glucose concentration and blood pressure between the two groups. However in group 2, significant increases in serum creatinine and blood urea nitrogen (BUN) were noted. Interestingly, no significant changes in renal function were noted in group 1.<BR>Although further studies are necessary, this study indicated that protein restriction therapy might be beneficial in preventing the progression of diabetic nephropathy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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