Effect of hemodialysis on insulin receptor binding of erythrocytes in diabetic or non-diabetic renal failure patients.
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Effect of hemodialysis on insulin receptor binding of erythrocytes was studied in chronic renal failure patients with diapetes (DN, n=7) or without diabetes (ND, n=7). There was a significant decrease in insulin binding before hemodialysis in both groups compared with healthy controls [DN: 3.4±0.5, ND: 4.2±0.8 vs N/C: 7.9±0.4%(p<0.05)]. In the DN group, there was a significant increase in insulin binding after hemodialysis [3.4±0.5% vs 5.8±0.8%(p<0.05)]. Scatchard analysis indicated that this change was due to an increase in the affinity of receptors for insulin.<BR>To investigate the mechanism of change in insulin receptor binding in uremia, in vitro incubation studies with uremic serum or methylguanidine (MG) were carried out. Insulin binding was decreased in a dose-dependent manner at a MG concentration ranging from 10 to 100 ng/ml. There was a tendency for improvement in insulin binding 12 hours after elimination of MG from the medium (from 81±6% to 83±8%). In the uremic serum experiments, insulin binding increased significantly 12 hours after elimination of serum from the incubation medium [from 69±2% to 78±3%(p<0.05)].<BR>These results suggest that some factors, such as MG, in uremic serum have inhibitory effects on insulin receptor binding.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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