Relationship between characteristics of anti-insulin antibodies and immunologic effects of human insulin therapy in insulin-treated patients.
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Anti-insulin antibodies were studied in 13 insulin-treated patients in reference to effectiveness of human insulin.<BR>In seven patients, in whom antibody-bound insulin declined markedly after treatment with human insulin, anti-insulin antibodies showed a higher proportion of high-affinity binding capacities than did those in another six patients before treatment with human insulin. The ratio of high-affinity binding capacity to low-affinity binding capacity (H/L) was related to percent decrease of antibody-bound insulin.<BR>When the H/L ratios were determined in 31 insulin-treated patients, high H/L levels were obtained in patients with bovine insulin therapy, patients treated with porcine insulin showed low H/L levels, and those treated with human insulin showed the lowest levels of all. In patients treated with mixed bovine-porcine insulin, H/L ratios were distributed over a wide range.<BR>It is concluded that the H/L ratio is dependent upon the animal species of insulin preparations, and that it is the predictor of immunologic effect in human insulin therapy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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