Anti-atherogenic effect of apple fiber on plasma apoproteins in NIDDM.
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The present study was undertaken to elucidate the effect of apple fiber (AF) on plasma apoproteins in non-insulin dependent diabetic patients. Fourteen diabetics (2 males and 12 females) ingested 15 g of AF per day for 16 weeks.<BR>Apoprotein AI was significantly (p<0.01) increased from 119±6mg/d<I>l</I> (mean±SE) to 141±5mg/d<I>l</I>, and apoprotein B was significantly (p<0.05) reduced from 151±9mg/d<I>l</I> to 131±8mg/d<I>l</I> after administration of AF. The apoprotein atherogenic index, estimated as the ratio of apoprotein B to AI, was significantly (p<0.01) reduced from 1.29±0.08 to 0.95±0.07, There was a positive correlation between plasma low-density lipoprotein cholesterol levels and plasma apoprotdn B levels before (r=0.765, p<0.01) and after (r=0.718, p<0.01) administration of AF. There was also a positive correlation between plasma high-density lipoprotein cholesterol leves and plasma apoprotein AI levels before (r=0.822, p<0.001) and after (r=0.760, p<0.01) administration of AF, and there was a positive correlation between changes in plasma high-density lipoprotein cholesterol and apoprotein AI (r=0.575, p<0.05).<BR>These findings indicate that changes in plasma apoproteins after administration of AF can be considered antiatherogenic, and AF may represent a useful adjuvant in the dietary management of diabetes.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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