Comparative analysis of glucose homeostasis during recovery period after total or partial pancreatectomy. Analysis using an artificial endocrine pancreas.:Analysis Using an Artificial Endocrine Pancreas
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Up to now, there have been few reports on the effects of the remnant or auto-transplanted pancreas on blood glucose homeostasis, especially during the postoperative recovery period.<BR>In this study, in order to precisey evaluate the insulin requirement during the postoperative recovery period in both partially (group I) and totally (group II) pancreatectomized subjects, we attempted to carry out blood glucose control in 11 paitents (group I; n=5, including 3 with segmental pancreas auto-transplantation after total pancreatectomy, group II; n=6) using an artificial pancreas (STG 11 A, Nikkiso, Shizuoka).<BR>After 8h, in both groups, blood glucose levels were normalized and found to have reached a steady state. Although initial and terminal blood glucose and the decrement of blood glucose concentration while using the artificial pancreas were the same in both groups, total insulin requirements and mean insulin infusion rates were significantly higher in group II than in group I total insulin requirements: group II; 42±16vs. group I; 14±5U/8h (p<0.01), mean insulin infusion rate: group I; 7.6+2.9 vs. group II; 2.7±0.8×B (1×B=0.225mU/kg/min)(p<0.01). There were patientto-patient variations in the insulin infusion pattern in group II. Total plasma catecholamine, and cortisol levels were found to be significantly elevated in both groups during the postoperative recovery period, but there were no significant differences between the two groups. Only plasma C-peptide levels were significantly higher in group I than in goup II.<BR>From this study with the aid of an artificial endocrine pancreas, it was suggested that endogenous insulin from the remnant pancreas might play an important role in blood glucose homeostasis even in the postoperative period.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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