Hypouricemia in non-insulin-dependent diabetic patients.
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概要
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Uric acid metabolism was studied in 276 non-insulin-dependent diabetic (NIDDM) patients and in 44 normal subjects. Compared with normal subjects, 204 non-proteinuric NIDDM patients had a significantly lower serum uric acid level (male: 5.21±1.33mg/dl vs 6.52±1.48, p<0.001; female: 4.57±1.17 vs 5.37±1.24, p<0.01). In these patients, uric acid level was inversely correlated to 2-h postprandial plasma glucose level (male: r=-0.239, p<0.05; female: r=-0.208, p<0.05). The indices of renal function of 100 non-proteinuric NIDDM patients and normal controls were compared. With respect to blood urea nitrogen, serum creatinine, creatinine clearance (Ccr), urinary uric acid excretion rate and urine volume, no significant difference was found between these two groups. Only the uric acid clearance (Curate) was higher in non-proteinuric NIDDM patiens than in normal controls (male: 5.90±3.37ml/min/1.48m2 vs 4.43±1.64, p<0.05; female: 6.77±3.39 vs 4.93±2.50, p<0.05). In 72 proteinuric NIDDM patients, serum level and urinary excretion of uric acid were investigated. Although the proteinuric patients, whether or not they received diuretics, had a higher uric acid level than the non-proteinuric patients, Cuarte/Ccr was inversely correlated to Ccr in these proteinuric and non-proteinuric patients. Thesse data indicate that serum uric acid level in non-proteinuric NIDDM patients is significantly lower than in normal subjects and is chiefly caused by inreased Curate in NIDDM patients.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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