A new diabetic strain of rat with exocrine pancreatic insufficency. (1st report).
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Spontaneously developed diabetes mellitus was observed in aged males of an inbred strain of Wistar rats, WBN/Kob. Non-obese male WBN/Kob rats developed glycosuria and hyperglycemia at about 6 months of age. The cumulative incidence of diabetes was 43%(33 out of 76) at 12 months of age and reached 90% at the age of 21 months. Diabetic rats were hypersensitive to exogeneous insulin, but showed no significant decrease in plasma glucose level when treated with oral tolbutamide. Serum levels and urinary excretion of amylase in WBN/Kob rats were significantly higher than those in control Wistar rats.<BR>The pathophysiology of this diabetes mellitus was quite different from that of type I or II diabetes mellitus in man and animals. A new strain of spontaneously developed diabetic rats with exocrine pancreatic insufficiency was established.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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