A case of insulin-dependent diabetes mellitus with Coxsackie B3 virus infection following diaminodiphenyl sulfone(DDS) syndrome.
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Coxsackie B<SUB>3</SUB>virus infection, as well as that of Coxsackie B<SUB>4</SUB>or B<SUB>5 </SUB>virus, has been suggested to be one of the pathogenic factors in insulin-dependent diabetes mellitus (IDDM). However, there are few reported cases of Coxsackie B<SUB>3</SUB>virus infection followed by IDDM. In this communication, a case of IDDM with Coxsackie B<SUB>3 </SUB>virus infection following DDS syndrome is reported. A 60-year-old female patient suffering from DDS syndrome was treated with predonine. Three weeks later, she suddenly complained of thirst and polyuria with accompanying hyperglycemia and ketouria. IDDM was diagnosed from such examinations as insulin release and HLA typing. Coxsackie B<SUB>3</SUB>neutralizing antibody titer quadrupled immediately after the onset of IDDM, rose by as much as 128 times after three weeks and then fell to four times after two months. Other viral neutralizing antibody titers did not change significantly. Therefore considering the time course of IDDM and changes in Coxsackie B<SUB>3</SUB>virus neutralizing titers, it seems probable that Coxsackie B<SUB>3</SUB>virus infection was pathogenic for the onset of IDDM in this patient.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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