Regulation of insulin requirement by gastric emptying in diabetic patients.
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Diabetic patients with autonomic neuropathy often show delayed gastric emptying. Delayed emptying of gastric contents may lead to delayed postprandial increase of blood glucose level. In this study, we examined the relationship between gastric emptying time and postprandial insulin requirement (PIRR) as determined by artificial pancreas (Biostator®) during feedback control of blood glucose level, and the possibility of improved blood glucose contorol by the recovery of gastric emptying time.<BR>Gastric emptying time was determined by <SUP>99m</SUP>TC-Tin-colloid labeled scrambled egg meal served with 2 slices of toast and 200 m<I>l</I> of milk, (590 kcal). PIRR was calculated from infused insulin doses during a 2-hour period after the meal under the artificial pancreas.<BR>Patients without gastropathy had a PIRR of 11.7±5.3 units (M±SD), whereas those with gastropathy had a PIRR of 5.6±2.1 units (during the 2-hour period after the meal, p<0.05). There was a highly negative correlation between the isotope remaining teh stomach and PIRR during the 2-hours after the meal (r=-0.84, p<0.005). Blood glucose control of diabetes was significantly improved by the recovery of gastric emptying time.<BR>Abnormal gastric emptying is an important factor in unstable diabetes mellitus. Normalization of gastric emptying time may be useful in blood glucose control.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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