Studies on the natural history on non-insulin dependent diabetic(NIDDM) patients based on long-term observations. (1). Mortality and associated risk factors.:Mortality and Associated Risk Factors

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A total of 1, 939 non insulin dependent diabetic patients (1, 200 males and 739 females) who were first seen between 1960 and 1979 at our hospital were followed until the end of 1984, a mean observation period of 9.4 years, and their prognosis and associated risk factors were studied.<BR>The mortality rates per 1, 000 person-years during the observation period were 31.35 for males and 21.99 for females, and they tended to increase with age. The O/E ratios, a ratio of observed number of deaths over expected number of deaths, computed based on the mortality statistics from Osaka Prefecture during the study period, were 1.69 and 1.74 for males and females, respectively, increasing as age at entry into the study became younger<BR>The mortality rates and O/E ratios in the age group under 35 years improved markedly during the past 25 years. The mean age at death and the mean duration from onset to death also revealed an apparent improvement during the same period.<BR>It was found that albuminuria was a common risk factor to the mortality of the patients of all age groups, in addition to fasting glucose level and type of treatment for those under 45 years at entry; age, sex, systolic blood pressure, retinopathy, and fasting glucose level for those 45-64 years; and age and sex for those 65 years or older.
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