Analysis of spleen lymphocyte subsets in Cyclosporin-treated NOD mice.
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Changes in the subsets of spleen lymphocytes in non-treated and Cyclosporin (Cs)-treated NOD mice were anaylsed using immunofluorescent techniques by FACS. The number of spleen cells in non-treated NOD mice aged 120 days was significantly more decreased than that in ICR mice of the same age. All of the percentages of Thy 1.2, Lyt 1 and Lyt 2 positive cells in non-treated NOD mice were significantly increased compared with those in ICR mice. Moreover, both percentages of Thy 1.2 and Lyt 1 positive spleen cells in Cs-treated NOD mice were significantly decreased compared with those in non-treated NOD mice, while no significant difference was observed in the percentage of Lyt 2 positive spleen cells between non-treated and Cs-treated NOD mice. The ratio of Lyt 1+ cells/Lyt 2+ cells in Cs-treated NOD mice was significantly more decreased than that in non-treated NOD mice. These results suggest that Cs may exert its suppressive effect on development of insulitis in NOD mice by altering the compartmentalization of lymphocyte subsets.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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