Plasma granulocytic elastase (.ALPHA.1-proteinase inhibitor-elastase complex) in diabetic patients.
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概要
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Granulocytic elastase (α<SUB>1</SUB> PI-EL) is a neutral protease contained in the lysosomes of granulocytes which is closely related to inflammation. In addition to its role as a factor in inflammatory diseases, it is suspected that granulocytic elastase has an antiatherogenic effect similar to that of pancreatic elastase.<BR>We have measured plasma al PI-EL levels in 78 diabetic patients, who had no clinical signs or symptoms of inflammation, and the following results were obtained.<BR>1)α<SUB>1</SUB> PI-EL levels in diabetics were significantly (p<0.001) higher than those in healthy individuals.<BR>2) There was no relationship between α<SUB>1</SUB> PI-EL levels and other ihflammatory parameters.<BR>3)α<SUB>1</SUB> PI-EL levels were significantly high in diabetics who had diabetic complications and longer durations of diabetes.<BR>These findings suggest that granulocytic elastase is closely related to clinical aspects of diabetes mellitus, and is expected to become a new index which is available for evaluating diabetic complications.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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