Cholinergic neurons in the CNS and glucoregulation.
スポンサーリンク
概要
- 論文の詳細を見る
In order to clarify the characteristics of cholinergic neurons in the CNS with respect to glucoregulation, various cholinergic agonists and antagonists were injected into the third cerebral ventricle and changes in hepatic venous plasma glucose, glucagon (IRG) and insulin (IRI) were studied.<BR>Carbachol, muscarine, bethanechol, acetylcholine and methacholine injected into the third ventricle resulted in hyperglycemia. However, no hyperglycemic response was observed after nicotine and DMPP injection into the third ventricle.<BR>The microinjection of neostigmine produced marked and sustained hyperglycemia dose-dependently (1×10<SUP>-9</SUP>-1×10<SUP>-7</SUP> mole) associated with IRG elevation and relatively lower IRI secretion. Neostigmine-induced hyperglycemia was inhibited by bilateral adrenalectomy.<BR>Coadministration of atropine with neostigmine into the third ventricle prevented glucose and IRG elevation, while hexamethonium did not modify the neostigmine-induced hyperglycemia.<BR>These results suggest that the accumulation of endogenous acetylcholine in the CNS increases in hepatic glucose production through adrenal mechanisms and that the cholinergic receptor in the CNS is of the muscarinic type.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
- Hyperlipidemia and Analysis of the Use of Lipid-lowering Drugs in Non-insulin-dependent Diabetes Mellitus.
- Thyrotoxic Crisis in a Patient with Mitochondrial Diabetes Mellitus.
- Rapidly Progressive Nephropathy in a Young Patient with Mitochondrial Gene Mutation.
- An Autopsy Case of Ketoacidosis in Insulin Dependent Diabetes Mellitus Patient Complicated with Adult Respiratory Distress Syndrome, DIC and Leukopenia.
- Studies on Alcoholic Beverages in Relation to Body Weight for Mild Diabetics