A case of aplastic anemia presumably caused by chlorpropamide administration.
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A case of chlorpropamide-associated aplastic anemia is described. A 46-year-old diabetic man began to complain of breathlessness and easy fatiguability after administration of about 35g of chlorpropamide in February 1982. The peripheral blood cell count showed pancytopenia (Hb 6.6g/d<I>l</I>, WBC 2, 200/mm<SUP>3</SUP>, platelets 15, 000/mm<SUP>3</SUP>). Bone marrow aspiration revealed a hypoplastic marrow. Chlorpropamide was discontinued and subcutaneous insulin administration was started to control the high blood glucose. The patient was treated with Prednisolone for 7 weeks with satisfactory improvement in peripheral blood cell counts (Hb 10.2g/d<I>l</I>, WBC 5, 200/mm<SUP>3</SUP>, platelets 180, 000/mm<SUP>3</SUP>) as well as in the bone marrow. His clinical course suggested that the aplastic anemia was secondary to chlorpropamide administration.<BR>So far 17 cases of hematological disorders associated with chlorpropamide have been reported. In most cases the illness developed when the total doses given amounted to nearly 10g. Only one case of aplastic anemia and two cases of bone marrow hypoplasia were included in these reports. Four patients with granulocytopenia died.<BR>Peripheral blood cell counts should be performed to avoid side effects during chlorpropamide administration.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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