Evaluation of the FPG-HbA1c system in mass screening for diabetes mellitus.

概要

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Although the oral glucose tolerance test (OGTT) has been the key examination in diagnosing diabetes mellitus, this test has some problems it is time consuming, requires frequent blood sampling many blood samplers. We investigated the usefulness of the HbA1c level in mass screening for diabetes mellitus. Mass screening for diabetes mellitus in adults as performed in Funagata and Oguni, Yamagata Prefecture, in 1982 and 1983. Examination of urinary glucose excretion after supper was done as the first step, and in the second step, the 75g OGTT and fasting levels of HbA1c examined for 586 cases with glucosuria. According to the diagnostic criteria of the Japan Diabetes Association for the 75g OGTT, 170 cases were classified as normal type, 293 cases as borderline and 123 cases as diabetic type. HbA1c levels in each OGTT type were 4.90±0.46%, 5.00±53% and 6.45±1.57%(mean±SD), respectively. Since it is possible to measure fasting levels of plasma glucose (FPG) and HbA1c, with a single blood sampling, the screening procedure for diabetes mellitus was simplified. Namely, we obtained the following equation by discriminant analysis for these parameters f=30 × HbA1c +FP-270. In this equation, positive f-values indicate diabetic type negative values indicate non-diabetic type. Thus, the "FPG-HbA1c system" was very useful for mass screening of diabetes mellitus.
一般社団法人日本糖尿病学会の論文