:Especially the Prognosis and Causes of Death in Juvenile-Onset Diabebtic Patients
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The relationship between the prognosis and the age at onset of diabetes, especially the prognosis of juvenile-onset diabetic patients in recent years in Japan, was studied based on a long-term observation. The subjects studied were 1, 900 diabetic patients of whom all were type 2 diabetics, except for 12 cases of type 1 diabetes.<BR>1) The mean annual mortality rates (per 1, 000), computed based on person-year observation, were 30.79 for males and 20.10 for females as a whole, increasing with age. The rates were 18.53 and 15.81 for males and females, respectively, in the subjects who developed diabetes at the age of less than. 35. However, O/E ratios, ratios of observed over expected number of deaths, based on the mortality statistics from Osaka Prefecture during the observation period, were highest in the subjects with the onset at less than 35 and decreased with age.<BR>2) The analysis of baseline characteristics by the age at onset revealed the highest fasting glucose level, the largest proportion of insulin-treated patients and a relatively high prevalence of albuminuria in the subjects with the onset at less than 35.<BR>3) The most common cause of death was renal disease including diabetic nephropathy, with an extremely high O/E ratio, followed by heart disease, malignant neoplpsms and cirrhosis of the liver, in the subjects with the age at onset before 35 years, indicating a sharp contrast of distribution of causes of death in the subjects with the age at onset of 65 or more, in which the leading causes of death were malignant neoplasms, heart disease and cerebrovscular disease.<BR>As a conclusion, the prognosis of the subjects with the onset of diabetes at less than 35 years of age was noteworthy: a high relative mortality risk and an increased risk of dying from renal disease, suggesing a possible relationship with the baseline characteristics.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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