Decreased amylase activity of the pancreas in NOD mice.
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概要
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The exocrine pancreas of NOD mice, a spontaneous animal model of type I diabetes, was compared with that of ICR mice. The pancreatic IRI content and amylase activity in NOD mice aged three and five weeks, which were devoid of hyperglycemia and insulitis, showed almost the same levels as those in age-matched ICR mice. On the other hand, these same values, in NOD mice three to five months of age and with insulitis were decreased modertely in the normoglycemic and markedly in the hyperglycemic groups as follows: The ratio of the pancreatic IRI content in NOD mice vs ICR mice was 0.59 in normoglycemic mice and 0.014 in hyperglycemic animals; the ratio of pancreatic amylase activity was 0.57 and 0.11, respectively.<BR>Thus, the amylase activity of the pancreas in NOD mice was already decreased when insulitis was present, and the insulin content was decreased in this organ even in a normoglycemic state. Furthermore, this decreased amylase activity was markedly aggravated in a diabetic state with severe insulin deficiency in the pancreas.<BR>This result may suggest that the exocrine pancreatic disturbance observed in NOD mice, at least in part, has a close relationship to a depletion of the insulin content accompanied by insulitis in this organ.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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