Functional interrelationships of the exocrine and endocrine pancreas; Exocrine pancreatic function in rats with insulin-secreting islet-cell tumors.:Exocrine Pancreatic Function in Rats with Insulin-Secreting Islet-cell Tumors

概要

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Pancreatic exocrine function in hyperinsulinemia was studied in the rat with islet-cell tumors (ICT) induced by streptozotocin and nicotinamide in the in vitro isolated perfused pancreas. A significant amount of insulin was detected in the portal effluent from the pancreas with ICT, even in the hypoglycemic state. (2.8 mM glucose). In addition, the pancreas with ICT secreted an extremely high amount of insulin in response to both glucose (8.3 mM) and caerulein (0.1 ng/m<I>l</I>) stimulation. However, the function of normal B cells in the pancreas with ICT was assumed to be suppressed by the preexisting tumor-induced hyperinsulinemia, since the insulin secretory response to glucose and caerulein after removal of ICT was less than that of the control pancreas from which a similar weight of normal pancreatic tissue had been removed. On the other hand, the amylase output from the ICT pancreas in response to 0.1 ng/m<I>l</I> of caerulein, both before and after removal of ICT, was significantly lower than that from the control, although there was no difference in pancreatic juice flows from the two groups. These results suggest that local high concentration of insulin around the acinar cells via the islet-exocrine portal system through the exocrine tissue is more important in maintaning acinar cell function than regional or systemic hyperinsulinemia induced by islet cell tumors.
一般社団法人日本糖尿病学会の論文