Decreased prostacyclin production and platelet abnormalities in diabetes mellitus.
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概要
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Prostacyclin (PGI<SUB>2</SUB>) mainly produced from vascular walls has an inhibitory effect on platelet aggregation. It has been reported that, in diabetes mellitus, PGI<SUB>2</SUB> production is decreased and platelet thromboxane B2 (TXB<SUB>2</SUB>: a stable metabolite of thromboxane A<SUB>2</SUB>) production is increased, leading to vascular complications. In this study, the relationship between plasma 6-keto-prostaglandin F<SUB>1α</SUB> (6 KF: a stable metabolite of PGI<SUB>2</SUB>) level and platelet function in diabetes mellitus was examined.<BR>Plasma 6 KF level was significantly decreased in diabetics with proliferative retinopathy (DP) compared with age-matched controls (247.1±41.8 vs. 378.4±45.5pg/m<I>l</I>). On the other hand, platelet aggregation rate (78±4%) and TXB2 production during aggregation (8.34±1.70 nmol/10<SUP>10</SUP> platelets) were significantly increased in DP compared with controls (37±9, 2.60±0.56), respectively. It was observed that plasma 6 KF level was significantly inversely correlated with platelet aggregation rate and TXB<SUB>2</SUB> production during aggregation. On the other hand, samples of aorta obtained from streptozotocin-induced diabetic rats produced less PGI<SUB>2</SUB>-like substance than samples from controls.<BR>These results suggest that decreased plasma PGI<SUB>2</SUB>, which would be derived from decreased aortic production, may be one of the causes of abnormal platelet function in diabetes mellitus.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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