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Glycosylated hemoglobins (HbA<SUB>1</SUB> or HbA<SUB>1c</SUB>) have been widely used for assessing the long-term control of diabetes. Apart from this, nonenzymatic glycosylation of serum proteins has evoked special interest in relation to its role in the development of diabetic complications. In the present study, the glycosylation of serum low density lipoprotein (LDL) and of serum protein in diabetic patients was determined to substantiate its usefulness as an index for the short-term control of diabetes, since the half-lives of these proteins are much shorter than that of HbA<SUB>1</SUB>.<BR>Glycosylated LDL (GLP) and serum protein (GSP) were assayed by the thiobarbituric acid reaction, and their values were expressed as nanomoles of 5-hydroxymethylfurfural (HMF) per mg protein. The level of GLP in diabetics was significantly higher than that in nondiabetics (4.4±1.6 and 1.7±0.6, respectively; p<0.001), and correlated remarkably with the mean value of the fasting blood sugar (FBS) for one week (r=0.69). The level of GSP in diabetics was higher than that in nondiabetics (1.0±0.3 and 0.5±0.2, respectively; p<0.001), and correlated well with the mean FBS for two weeks (r=0.62). These results indicate that GLP and GSP might provide a valuable tool for assessing the shortterm control of diabetes. Moreover, it was demonstrated that the degree of glycosylation of LDL was greater than that of other serum proteins. A high value of GLP with probable changes in qality may play an important role in the development of diabetic angiopathy.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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