:Hypoglycemic Agents in Patients with Diabetic Retinopathy-III. Results 2 (FBG, Platelet Adhesion, Plasma Lipids, Body Weight and Drugs)
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A long-term comparative clinical trial with oral hypoglycemic agents was performed to assess their efficacy in diabetic retinopathy. In the preceding papers, the objective of the trial and the methods used were discussed along with some background factors of the patients treated, the degree of satisfaction with the treatment of diabetes, and the relative safety of the drugs studied. This paper deals with the fasting blood glucose, serum lipids and patient's body weight as indices of control of diabetes together with the characteristic effects of Gliclazide (SE) on platelet adhesiveness and the equivalent doses of oral hypoglycemic agents as information that is useful in the clinical application of SE in actual practice. The degree of control of fasting blood glucose was essentially parallel with the degree of satisfaction with the treatment of diabetes: the fasting blood glucose was well controlled in 73.1 per cent of the patients on Diet alone as compared with 51.9 per cent with SE and 40.5 per cent with SU. As to the serum lipids, no marked difference was present among the three groups in total cholesterol or triglyceride, whereas HDL cholesterol was more satisfactorily controlled in patients receieving SU. The body weight of patients was somewhat increased with SE, tended to decrease with SU and remained almost unchanged with Diet. The actual dosage of SE ranged from 5-240 mg daily with a mean of 80 mg daily. Estimation of equivalent doses of the drugs studied and other oral hypoglycemic agents showed that one tablet (40 mg) of SE is as potent as 500 mg of tolbutamide, 250 mg of acetohexamide, 1.25 mg of glibenclamide or 125 mg of chlorpropamide.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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