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The nature and mechanism of the pancreatic dysfunction which accompanies diabetes mellitus was evaluated directly <I>in vitro</I> using isolated perfused pancreasprepared from normal and streptozotocin-induced diabetic rats.<BR>Diabetes was produced by intravenous injection of 45 mg/kg streptozotocin to 16-18 hr fasted rats. Twelve days after the injection, the diabetic rats were used for the experiment. The streptozotocin treated rats lost about 20 g body weight after the injection, whereas control rats gained about 50 g. The pancreatic wet weight of diabetic rats was significantly lower than that of control rats, but not when related to body weight. The protein content in the pancreas of diabetic rats was significantly decreased when calculated per pancreas, but not when calculated relative to the wet weight of the pancreas. The pancreatic amylase content in diabetic ratswas significantly lower than that in control rats, irrespective of whether it was calculated per pancreas or per protein. The output of pancreatic juice from diabetic rats was the same as that from control rats. The total and peak amounts of amylase and protein secreted from the diabetic rat pancreas in response to 0.1 ng/m<I>l</I> caerulein were significantly lower than those from control rats.However, the amount of amylase and protein released relative to the initial pancreatic content from the diabetic rat pancreas was similar to that from the control rat pancreas.<BR>The present findings indicate that the diabetic rat pancreas hasnormal responsiveness to secretagogue, although the pancreatic amylase content was significantly reduced.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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