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To determine the factors that may contribute to the development of hypertriglyceridemia, we measured insulin binding to erythrocytes and postheparin plasma lipase activities in obese children and investigated whether these and other parameters were related with the serum triglyceride level. Insulin receptor binding to erythrocytes was assayed according to the method described by Gambhir et al. Activities of postheparin plasma lipoprotein lipase (LPL) and hepatic triglyceride lipase (HT GL) were measured by an immunochemical method utilizing an antiserum raised against HTGL. Postheparin plasma was obtained five minutes after administration of heparin at a dosage of 10 unit/ kg body weight or at a corrected dose that was calculated to compensate for the disproportion between body mass and plasma volume in obesity. Thirty-five obese children without fasting hyperglycemia (24 males and 11 females; ages ranging from five to 16 years) were studied. Thirty non-obese children served as controls for the serum lipid levels and two lipase activities.<BR>Hypertriglyceridemia was common (57%) in obese children. Insulin binding to erythrocytes was inversely correlated with the logarithmic values of fasting serum insulin concentration (n=18), of the insulin area under the O-GTT insulin response curve (n=18) and of the serum triglyceride level (n=20). The LPL activity in obese children both at 10 unit/kg body weight of heparin (n=13) and at a corrected heparin dose (n=12) was similar to that in controls, suggesting that hypertriglyceridemia in these children was not due to the impairment of triglyceride removal. The serum triglyceride level was correlated with the fasting serum insulin concentration (n=29) and insulin area (n=20). Percent ideal body weight was also correlated with the latter two variables, while it was correlated with neither insulin binding nor the serum triglyceride level.<BR>It was concluded that insulin resistance and hyperinsulinemia in obese children may be the major contributing factors in the development of hypertriglyceridemia, which is idependent of the degree of obesity and postheparin plasma LPL activity.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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