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With the purpose of performing a genetic analysis on the interaction between the genotype responsible for fasting blood sugar (FBS) value and environment, the data of Kitazawa et al. (1979) were used to estimate mean FBS, variance, distribution of minimum and maximum values and +gene frequency responsible for FBS by age and year.<BR>Regression analysis of these estimated values by aging and year was performed, and the following was found. (1) The regression coefficients by aging that were statistically significant were mean value and variance. In this case, a trend for linear regression is shown. Hardly any significant relationship could be found in the distribution of minimum and maximum value and +gene frequency. However, of these distributions, the observed maximum value showed a significant difference from the expected value and this is not compatible with the linear or quadratic regression. However, the values showed a trend to increase with age. (2) Of the regression coefficients by year, those that reached a statistically significant level were the mean value and variance in only the 40-to-49-year age group. The maximum value of variance and distribution showed poor correlation with the regression coefficients. Further, in hardly any did the +gene frequency reach a significant level.<BR>In view of the above-mentioned series of trends, the increase in the hyperglycemic group due to aging and changes with year was already expected to occur in accordance with the increase of gene effects caused by aging and changes with year on the basis of the model reported by Furusho (1982). However, it is difficult to estimate the effects of aging by year alone from the results of this study. The reason for this is that changes in life-style after the termination of World War IIwere remarkable. For example, as the living environment of those in their 20s and those in their lOs differ greatly, the effects of the environment are included in the effects of aging. A model to analyze this point was also devised, but as there are not any data available at present for such an analysis, it will have to be deferred as problem for the future.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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