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Genetically diabetic KK mice were given a limited diet daily from four to seven months of age. After this treatment, diabetic-like glomerular lesions and their correlation with intolerance to glucose and β-glycosidase activities in serum, liver and kidney tissue were investigated<BR>(1) The limited diet lowered the extent of glucose intolerance (p<0.01), body weight (p<O.001), serum insulin level (p<0.001), kidney weight (p<0.001) and kidney/body weight ratio (p<0.01).<BR>(2) Morphometric study revealed that KK mice given the limited diet had significantly decreased glomerular areas (p<0.001) and GBM widths (p<0.001) as compared with those fed ad libitum.<BR>(3) Immunofluorescent microscopic study showed a significant deposition of mouse IgA or IgG mainly in the mesangium and sometimes along the capillary wall of the glomeruli in the mice fed ad libitum. On the other hand, the staining intensity of the fluorescence for IgA or IgG decreased prominently in KK mice given the limited diet.<BR>(4) The limited diet lowered 1S-N-acetylglucosaminidase activity in the serum (p<0.05) and increased jS-N-acetylglucosaminidase (p<0.001) and jS-galactosidase activities (p<0.02) in the liver, but not in the kidney. The increase in glycosidase activities of liver tissue may be due to improved liver lesions including severe fatty degeneration, by treatment with the limited diet.<BR>(5) Dietary limitation of genetically diabetic KK mice effectively improved the intolerance to glucose and suppressed the progression of diabetic-like glomerular lesions
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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