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Plasma amino acid levels were analyzed in 4 cases of hyperosmolar nonketotic coma, 6 cases of diabetic ketoacidosis, one case of lactic acidosis before and after corrective therapy, and 7 normal controls. The results obtained were as follows.<BR>(1) In hyperosmolar nonketotic coma, the total amino acids were relatively low, and the amounts of arginine, taurine and serine were decreased both as the concentration and as the molar ratio. The concentration of ornithine was decreased. On the other hand, phenylalanine was increased both as the concentration and the molar ratio, and glutamic acid as the concentration also.<BR>(2) In diabetic ketoacidosis, leucine, isoleucine, glutamic acid, a-aminobutyric acid and valine were increased both as the concentration and as the molar ratio. Histidine, proline, and glycine + citrulline were increased only as the concentration. The level of taurine was lower both as the concentration and as the molar ratio, and that of serine as the molar ratio also.<BR>(3) In the one case of lactic acidosis associated with phenformin administration, tremendous increases in alanine, a-aminobutyric acid and proline were found together with increases in lysine, histidine, threonine, serine, asparagine, glutamine, glycine +citrulline, valine, methionine, isoleucine, leucine, phenylalanine and tyrosine. The concentrations of arginine, aspartic acid, glutamic acid and taurine did not show much change.<BR>The above results appear to indicate differences in the biochemical background to each diabetic coma.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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