糖尿病の細小血管症と血漿Soluble Fibrin Monomer Complexesとの関連性
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The plasma SFMC concentrations in normal subjects, diabetics without retinopathy, and diabetics without proteinuria were 4.9 ± 1.5, 7.2 ± 4.8, and 6.6 ± 3.8 mg/d<I>l</I>, respectively.<BR>There were no significant differences among these values, In the group with a high blood sugar level of more than 201 mg/d<I>l</I> including many cases of progressive proliferative retinopathy, the SFMC concentration was positively correlated with the blood sugar concentration (r = + 0.59) and also with the fibrinogen concentration (r= +0.71), but it was not related to the antithrombin-III, total cholesterol and triglyceride concentrations. The SFMC levels in diabetics with accompanying proteinuria of under or over 30 mg/dl were both significantly high, at 12.9±10. 1 and 15.2 ± 8.6 mg/dl, respectively.<BR>The SFMC levels in diabetics with retinopathies of Scott IIIa + b and Scott IV-Va were also increased to 14. 3 ± 7.5 and 21.8± 11.9 mg/dl, respectively, but were significantly high only in the group with accompanying proteinuria. The SFMC concentration and the conduction velocity of the aorta or the elastic rate of the carotid were not interrelated. These findings suggest that thrombin generation at some vascular lesions in such patients was indicated by the plasma SFMC production and appeared to accelerate the complication of vascular disorders.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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