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The effect of propranolol on reactive hypoglycemia was observed in 4 postgastrectomy patients for a variable time ranging from 2 to 7 months. Before the propranolol therapy was started, a 3-hours oral glucose tolerance test (OGTT) was given using 50 g of glucose. Each patient had a repeat OGTT on subsequent days at 15 min. after the oral administration of propranolol (10 mg). Propraolol preadministration reduced the mean peak blood glucose from 221.3 ± 23.7 mg/dl (mean±SE) to 174.0 ± 17. 8 mg/dl and the mean peak of immunoreactive-insulin from 126.8 ± 39.9μU/ml to 68.5±10.6μU/ml. It raised the lowest blood glucose from 69.5 ± 4.9 mg/dl to 78.3 ± 6.6mg/dl. However the mean plasma glucagon and human growth hormone remained unchanged.<BR>During the treatment with propranolol, all patients sohwed favorable clinical results as well as a significant increase in 2-hour postprandial blood glucose levels. However, no significant changes were observed in fasting and 2-hour postprandial mean plasma insulin and catecholamine levels.<BR>The improvement of clinical status induced by propranolol therapy may reflect hepatic changes of glucose metabolism that are not yet well understood. On the other hand, inhibition of insulin secretion appears to be the main reason by which improvement of clinical status is achieved.<BR>From a clinical viewpoint, propranolol therapy may be useful in postgastrectomy hypoglycemic patients.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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