Suppressive Effect of Ethanol on Insulin and Glucagon Secretion from Perfused Rat Pancreas
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The direct effects of ethanol on insulin and glucagon secretion were studied using isolated and perfused rat pancreas. Two series of experiments were performed. In one, the ethanol concentration in the perfusate was maintained at 21.7 mM, and in the other at 65 mM. The 65 mM ethanol suppressed more markedly both the first and second phases of insulin release induced by 16.7 mM glucose, compared to 21.7 mM ethanol. The 21.7 mM and 65 mM ethanol showed the same extents of inhibition of insulin and glucagon release to 6.4 mM arginine in the presence of 5.5 mM glucose.<BR>These findings suggest that ethanol exerts a direct inhibitory effect on the secretion of insulin and glucagon, and that ethanol inhibits glucose-induced insulin release in a dose-related manner.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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