Effect of Insulin Suppository on Daily Profiles of Plasma Glucose and Insulin Concentrations in Diabetic Patients
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The authors have reported in animal experiments that insulin suppository with Witepsol H-15 as the base and polyoxyethylene-9-laurylsulfate as the surfactant, was effective in lowering the plasma glucose concentration at a dose of as little as 2U/kg. No adverse effects or impairment of the rectal mucosae were ecognized.<BR>In the present study, the effects of insulin suppository so prepared on the responses in the plasma glucose and insulin concentrations and on the change in circadian profiles of plasma glucose, were examined in normal subjects and diabetic patients.<BR>The following results were obtained.<BR>1) In normal subjects, when 50 U/person (equivalent to 0.8 U/kg) or 100 U/person (equivalent to 1.6 U/kg) of insulin suppository was administered rectally, the immunoreactive insulin concentration (IRI) in the plasma became elevated up to 30μU/ml or 39μU/ml, respectively. When 100 U/person (equivalent to 1.8 U/kg) of insulin suppository was administered to diabetic patients, the mean peak in IRI was 64μU/ml, which was significantly higher than that of normal subjects. It was estimated from the area under the IRI curve that the fraction of insulin absorbed from the rectum was 2.6% on average in normal subjects, and 7.1% on average in diabetic patients.<BR>2) When 100 U/person (equivalent to 1.8 U/kg) of insulin suppository was administered 3 times a day to diabetic patients, postprandial hyperglycemia became markedly reduced. Subsequently, the amounts of daily urinary glucose excretion fell significantly.<BR>The above results suggest that plasma glucose regulation in diabetic patients may be possible with insulin suppository administration. However, for long-term clinical use, the development of preparations having high bioavailability is necessary.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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