Assessment of New Criteria for Diabetes by the Long-Term Prognosis
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概要
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The validity of the new criteria proposed by Keen et al. was assessed on the basis of longterm prognosis, using subjects who were found in an epidemiologic survey. The 10-year relative survival rates (RSR) were examined in relation to the OGTT categories by the new criteria at the base line. The prognosis of normal subjects (fasting glucose value (F)<140 mg/d<I>l</I> and 2-hour glucose value (2 HR)<140 mg/d<I>l</I>) and IGT 1 (F<140 mg/d<I>l</I> and 2 HR between 140 and 200 mg /d<I>l</I>, originally defined as IGT) did not differ from that of the general population in Japan. Diabetics, however, revealed a significant decrease in RSR (59.5 ±11.0%), demonstrating an excess mortality in this group. Since the definition of OGTT by Keen et al. was not exhaustive, the following two groups were added and also assigned to IGT in the present study: IGT 2 (F<140 mg/d<I>l</I> and 2 HR>200 mg/d<I>l</I>) and IGT 3 (F>140 mg/d<I>l</I> and 2 HR <200 mg/d<I>l</I>), These two groups behaved quite differently: the RSR was 106.8±11.1% for IGT 2 and 50. 3 ± 23.7% for IGT 3. In addition, if a single value was employed for the distinction between normal and abnormal subjects, the RSR was 84.3 ± 8.3% for those with 2 HR>200 mg/d<I>l</I> and 66.2 ± 10.1% for those with F>140 mg/d<I>l</I>, suggesting that the fasting value was an effective parameter for the diagnosis of diabetes.<BR>It is concluded that the new criteria, where the separation point was set at a much higher level, were broadly acceptable when examining the long-term prognosis of the subjects.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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