Treatment of Diabetes with Guar Gum and Its Effect on the Oral Glucose Tolerance Test in Healthy Subjects and Diabetics
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Western investigators have recently reported the effects of guar gum in loweringfasting serumcholesterol and post-prandial blood glucose levels. This substance, galactomannan, is a storage form of polysaccharide contained in the cluster bean, <I>Cyamopsis tetragonoloba</I>. We therefore determined whether guar gum is also effective in our diabetics whose dietary habits appeared to differ from those of Westerners.<BR>Five diabetic patients were given 18 g of guar gum over a 4-week period while taking their home diet. The patients comprised 4 obese adult-onset type diabetics, and one brittletype diabetic subject. The former showed a body weight loss of 1 to 3 kg during the period andtheir mean urinary glucose excretion fell by 80%. No remarkable changes in urinary glucose loss or body weight were observed in the latter subject. All patients experienced alleviationof post-prandial hunger sensation while taking the agent, but no remarkable adverse effects were seen.<BR>The effects of guar gum on blood glucose (BG), plasma IRI, glucagon immunoreactivity (GI) and gut hormone levels during a 50 g oral glucose tolerance test (OGTT) were investigated in 5 normals and 5 obese diabetics. In the normals, following the oral glucose load, the BG level fell below the basal level at 90 min but rose thereafter, giving a biphasic pattern. However, the BG level at 90 min in OGTT with 15 g of guar gum was significantly higher than the corresponding value for OGTT alone. The glucose tolerance curve was monophasic when guar gum was incorporated into OGTT. The plasma IRI levels tended to be comparatively higher at 30 min in OGTT alone and at 180 min in OGTT with guar gum. No significant difference in incremental area of IRI above the basal level (ΣΔIRI) was observed between these two tests. There was nodifference in patterns of plasma GI and gut hormone responses between OGTT and OGTT with guar gum, except for a lower plasma motilin Concentration in the latter test. In diabetics, the changes in BG, plasma IRI and gut hormone concentrations observed during OGTT with guar gumdid not significantly differ from those during OGTT alone.<BR>Guar gum, a dietary fiber, is considered to represent a useful adjunct in the dietary therapy of diabetes, particularly in obese adult-onset type diabetics. The mechanism of its effect is probably based on its satisfying action through delay of glucose absorption and its bulkiness.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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