A Report of a Case with Anaphylactic Reaction following Insulin Injection
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A 64-year-old female was admitted because of right upper abdominal pain. She had complained of a bout of colic pain at the right hypochondrium three years prior to admission and a diagnosis of gall stone was made. Glucosuria was found nine years before admission and since then, she had been treated irregularly with oral anti-diabetic drugs or insulin.<BR>On the 21st day of admission, insulin in amount of 0.1 U per kg of body weight (5.1 U) was injected intravenously in order to investigate responsiveness to insulin. Immediately after the insulin injection, the patient showed nausea, vomiting, a fall of blood pressure, a loss of consciousness and shock, which continued for 20 minutes and were relievee by the administration of epinephrine and prednisolone.<BR>Skin tests performed one month after the anaphylactic episode showed strong positive reaction for beef and pork insulin but very weak reaction for bonito insulin.<BR>During and after the operation for gall stone, her diabetic state was successfully controlled by bonito insulin.<BR>Insulin binding antibodies were demonstrated in her plasma after the operation, and showed reaction to beef insulin but little reaction to bonito insulin.<BR>The occurrence of reaginic antibody to insulin and diabetic control with bonito insulin were discussed.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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