Metabolism of Maltose Administered to Normal Rabbits
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A mixture of 10 μCi/kg of <SUP>14C</SUP>-U-maltose and 1 g/kg of 10% maltose solution was injected intravenously to normal rabbits and the radioactivities in blood, urine and several organs were determined.<BR>The blood maltose level decreased from 563 mg/100 ml at the time of 5 minutes to 17 mg/100 ml 4 hours after maltose injection. Blood glucose slightly increased from the fasting level of 150 mg/100 ml to 238 mg/100 ml 40 minutes after the administration of maltose. <SUP>14C</SUP>-maltose rapidly disappeared from the blood stream, reaching the base-line within 4 hours. In contrast, circulating <SUP>14C</SUP>-glucose rose gradually after the maltose injection and exceeded <SUP>14C</SUP>-maltose at the time of 90 minutes.<BR>In urine, 24% of total radioactivities was excreted as <SUP>14C</SUP>-maltose, 6% as <SUP>14C</SUP>-glucose and 12% as other <SUP>14C</SUP>-compounds.<BR>The changes in radioactivities in each organ were divided into two types. In the organs such as the kidneys, the liver, the small intestine, the brain or the muscle, <SUP>14C</SUP>-glucose levels exceeded the level of <SUP>14C</SUP>-maltose throughout the experiment for 12 hours. In the other organs such as the heart, the lungs, the lymph nodes, the large intestine or the pancreas, <SUP>14C</SUP>-maltose at the time of 20 minutes was higher than <SUP>14C</SUP>-glucose but thereafter <SUP>14C</SUP>-glucose exceeded <SUP>14C</SUP>-maltose which rapidly decreased after maltose injection. Approximately 10% of total radioactivities were observed in the skeletal muscle at the time of 60 minutes and the radioactivities were measured at the organs in order of the kidneys, the large intestine, the liver, the small intestine, the lungs and the heart.<BR><SUP>14C</SUP> -maltose was incorporated into glycogen in the heart and the muscle as much as <SUP>14C</SUP>-glucose was done. In the liver, however, the incorporation of <SUP>14C</SUP>-maltose into glycogen was minimum. In the brain, <SUP>14C</SUP>-glucose was detected whereas <SUP>14C</SUP>-maltose was not observed. In the gall bladder, 0.2% of total radioactivities was excreted for 6 hours.<BR>These experiments, indicate that 70% of <SUP>14C</SUP>-maltose injected to normal rabbits was metabolized in various organs in different patterns.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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