Skin Vascular Alterations and Calcification of Arteries of The Lower Extremity in Diabetes Mellitus
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概要
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In Europe and the United States, many observations have been published concerning histopathological changes of the cutaneous small blood vessels in diabetics, also many reports noted that the extensive arterial calcification in the lower extremities of diabetics. However, in Japan there have been only a few publications concerning the vascular alterations of the skin and the calcification of arteries in the extremities in diabetics.<BR>In this study the skin specimens obtained by a punch method from the calves of 157 diabetic and 176 nondiabetic subjects were examined by light microscopy, and the legs of 113 diabetics and 115 non-diabetics were examined roentgenorgraphically for finding the deposition of calcium in the arterial walls.<BR>The results in this study were as follows:<BR>1) Significant thickening of the skin vessel walls by the PAS-positive substance was found in 41% of the diabetics and in 12% of the non-diabetics. The difference in the two groups was statistically significant (p<0.01).<BR>2) Calcification of the arteries was found in 26% of the diabetics and in 7% of the non-diabetics. The differrence in the two groups was statistically significant (p<0.01).<BR>3) There was a positive correlation between the degree of the PAS-positive thickening of the skin vessel walls and the severity of diabetic retinopathy, while there was no correlation between the calcification of the arteries and the severity of diabetic retinopathy.<BR>4) In the diabetics, the degree of the PAS-positive thickening of the vessel walls showed no correlation with the sex or the age, while the arterial calcification was seen more frequently in the older subjects.<BR>5) In the diabetics, no correlation was found between the degree of the PAS-positive thickening of the skin vessel walls and the calcification of the arteries of the lower extremities.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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