Studies on Carbohydrate Metabolism in Kidney 1. Renal Gluconeogenesis in Experimental Diabetic Rats
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Renal gluconeogenesis was experimentally proved with kidney slices <I>in vitro. In vivo</I> it was proved, however, only in hypoglycemic state. The present paper deals with the renal gluconeogenesis in diabetic rats under eviscerated conditions.<BR>Method: Groups of normal rats, alloxan diabetic rats and steroid administered rats were each divided into two groups, i.e. one group of eviscerated rats with kidney and the other group of those without kidney. Decrease of blood sugar within one hour afth- evisceration, blood glucose entry ascertained by means C-glucose, and incorporation of C from C-actate into blood sugar were observed in each group above mentioned.<BR>The results are as follows:<BR>1) In normal rats, no significant differences in decrease of blood sugar after evisceration could be found between the group with kidney and that without kidney.<BR>2) In diabetic rats and steroid-administered rats, however, the rats of decrease of blood sugar in group with kidney was smaller than that of the group without kidney.<BR>3) The blood glucose entry in diabetic state occurred in the group with kidney. It hardly occured in the other group without kidney.<BR>4) Incorporation of C from C-lactate into into blood sugar was seen to small extent in normal rats underglucose loading condition. But it was seen to remarkable extent in diabetic state.<BR>It is suggested as follows:<BR>1) Eviscerated animals are useful for investigation on renal gluconeogenesis.<BR>2) Renal gluconeogenesis of normal animals under eviscerated condition was recognized to small extent in hypoglycemic state, and also to smaller extent under glucose loading condision.<BR>3) An increased renal gluconeogenesis in diabeticanimals under eviscerated condition would be due to endcrinological abnormality rather than to high blood sugar levels. It may be considered that kidney has also some regulation in diabetic state, as it is the case with liver.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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