Relationship between glossodynia and capsaicin sensitive sensory neurons-Examination of circulatory dynamics and immunohistochemistry-:Examination of circulatory dynamics and immunohistochemistry

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• Glossodynia is characterized by a burning sensation in the tongue, usually in the absence of other abnormal findings. For that reason, it is one of the most common psychosomatic disorders in dental practice, and yet in many cases it is difficult to treat. It is therefore now thought to be associated with physical factors.<BR>. We focused on disturbance of the blood flow of the tongue as a physical factor of glossodynia. The capsicum fruit has a pungent taste and produces a hot feeling throughout the oral cavity, occasionally causing pain. This pain, which is accompanied by a tingling burning sensation, is caused by capsaicin, the pungent active component of the capsicum fruit. Capsaicin sensitive sensory neurons respond to capsaicin. The terminals of these sensory neurons and their dorsal root ganglia contain transient receptor potential 1 (TRPV1). We hypothesized that TRPV1 plays an important role in the cause of glossodynia.<BR> We compared the blood flow of patients with glossodynia with that of healthy controls using laser Doppler and thermography. The results showed greater blood flow in the healthy controls than in the patients with glossodynia.<BR>In order to elucidate whether TRPV1 exists in the human tongue we used immunohistochemical staining and Western blot analysis. TRPV1 positive nerve fibers were recognized at various sites of the tongue mucosa, and in the taste buds as well. On Western blot analysis, a band was recognized around 95 kDa. Lafutidine is an H<SUB>2</SUB>-receptor antagonist that dilates blood vessels in the gastric submucosa and gastric mucosal tissue via TRPV1. We speculate that lafutidine may also be effective in glossodynia, because TRPV1 is also present in the tongue.<BR>The improvement rate of pain after administration of lafutidine was 49.4% at 2 weeks and 78.7% at 8 weeks. Average VAS of pain was 48.1 mm before medication, and 16.1 mm 8 weeks after administration. Therefore, we conclude that lafutidine not only improves disturbance of blood flow but also blocks TRPV1 in the tongue. TRPV1 is currently receiving considerable attention for its potential role as a new target substance for the management of pain. Further studies of TRPV1 are necessary.

• 特定非営利活動法人 日本口腔科学会の論文

特定非営利活動法人 日本口腔科学会 | 論文

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