Protein kinase C family as a molecular target for cancer chemotheraphy

概要

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Certain protein kinase C (PKC) isoforms expressed in cancer must play important roles in tumor promotion, tumor invasion and resistance to cytotoxic anti-tumor drugs. A variety of PKC inhibitors have been designed and their anti-tumor activities examined in many cancers. Safingol, a PKC a-selective inhibitor, induces endonuclease G-mediated apoptosis of human oral squamous cell carcinoma cells in a caspase-independent manner. Studies of the mechanisms of PKC inhibitors should contribute to the development of molecular targeting therapy for oral cancer.
特定非営利活動法人日本口腔科学会の論文