Experimental study for regeneration of dental hard tissue with human dental pulp cells into NOD/scid mice

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Tooth loss due to periodontal disease, trauma, tumor, or genetic disorders may significantly impair quality of life. A regenerated tooth for replacing a lost tooth would provide a useful alternative to available clinical treat mentswith dentures or dental implants. Despite ex tensiveknowledge of tooth development, little is known about the characteristics and properties of the dental stem cells in the postnatal organism.<BR>To assess the ability of human dental pulp cells to re generatedental hard tissue, we used a method that had been previously developed for tooth transplantation into NOD/scid mice. We present histologically-characterized dental hard tissue generated by pulp organ or dissoci ated pulp cells seeded onto collagen membranes. Our results revealed that postnatal dental pulp contains stem cells that are capable of regenerating dental hard tissue.<BR>On the other hand, tooth development is the cumula tiveresult of reiterative signaling of growth factors. We also examined the role of IGF-I (insulin-like growth factor-I) for tooth regeneration with the same strategy. Our results demonstrated that IGF-I serves as one of the important regulators of dentin and bone formation during tooth development.
特定非営利活動法人日本口腔科学会の論文