Allergic reaction originated from loxoprofen sodium; Report of a case.

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Allergic reaction induced by local anesthetics, antibiotics, or antiphlogistics is not common in the field of oral and maxillofacial surgery.<BR>A 29-year-old woman with perioral and eyelid edema presented in August 2000 about 1 hour after orally taking 60 mg loxoprofen sodium (Loxonin (R), Sankyo Co., Ltd., Tokyo, Japan) for pain of the lower right third molar. The skin lesions were diagnosed as an allergic reaction originated from loxoprofen sodium used to relieve pain from dental focal infection of the lower right third molar.<BR>An intracutaneous reaction test and provocative test revealed intense positivity. The histopathological diagnosis was superficial perivascular dermatitis consistent with drug-induced dermatitis. From these results together with her anamnesis and clinical history, we finally diagnosed the condition as allergic reaction caused by loxoprofen sodium.
特定非営利活動法人日本口腔科学会の論文