A Case of Extensive Erythroplakia of maxilla. An Immunohistochemical Study on Expression of PCNA, p53 Protein, and CD44v6.:An Immunohistochemical Study on Expression of PCNA, p53 Protein, and CD44v6

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An extensive erythroplakia was reported with the results of an immunohistochemical examination for PCNA, p53 protein, and CD44v6. A 69-year-old female was referred to the Hiroshima University Dental Hospital for a progressively enlarging red lesion with tenderness of the oral mucosa. Clinical examination revealed extensive red plaque involving the left hard palatal, buccal, and upper alveolar vestibular mucosae. Histological diagnosis of epithelial dysplasia (moderate) was made on the biopsy specimen. Surgical extirpation of the red lesion was performed as three separate operations. The mucosal epithelium in the surgical specimens showed a various degree of epithelial dysplasia. The frequency of PCNA-positive cells in the dysplastic epithelium was significantly higher than that in the adjacent normal epithelium. The expression of p53 protein was only observed in the dysplastic epithelial cells. In the severe dysplastic areas, p53 positive cells were numerous and widely distributed from the basal to superficial layers. On the other hand, the expression of CD44v6 on the cytomembrane was decreased and became heterogeneous in the dvsplastic epithelium.
特定非営利活動法人日本口腔科学会の論文