Immunohistochemical Study of EGFR Expression in the Excisional Wound of Hamster Tongue.
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概要
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The expression of epidermal growth factor receptor (EGFR) was investigated in the wound of hamster tongue. Fifty hamsters were used in this study. The tips of the tongues were excised with scissors, and then the animals were killed in groups of 5 at intervals of 1, 3, 5, 7, 9, 11, 13, 15 and 30 days. The tongues were studied histologically and immunohistochemically. Histologically, at 1, 3, and 5 days, the peripheral areas of wounds of all animals were covered with the parakeratinized epithelium, and the central areas of wounds exhibited fibrinous materials with some polymorphonuclear leukocytes on their surfaces. At 7, 9, 11, 13 and 15 days, the wounds were completely covered with the hyperkeratinized epithelium. At 30 day, the epithelia of the wounds were similar to the normal tongue epithelium. Immunohistochemically, at 1, 3, and 5 days, EGFR was uniformly present in keratinocytes at the migrating edge of the epithelium. At 7 day, the wounds were covered completely with the hyperkeratinized epithelium, and EGFR was present uniformly in all cell layers of this epithelium. At 9 and 11 days, however, EGFR was found to be reduced with time after 7 days. At 13 and 15 days, the basal cells only showed a positive staining for EGFR. At 30 day, the scattered basal cells expressed a positive staining for EGFR, the expression of which was similar to that of the normal tongue epithelium. It is suggested that the EGFR plays a regulatory role in the wound healing of the tongue.
- 特定非営利活動法人 日本口腔科学会の論文
特定非営利活動法人 日本口腔科学会 | 論文
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