Distribution of Neuropeptide Y-ergic Sympathetic and Parasympathetic Nerves within the Rat Submandibular gland.
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Neuropeptide Y (NPY), a 36-amino acid peptide, was isolated from porcine brain by its C-terminal tyrosine amide. NPY is believed to have nor adrenergic properties; however, not all NPY-immunoreactive nerve fibers have these properties.<BR>In this study, NPY-electropositive innervation of rat submandibular glands was investigated by immunohistochemical techniques.<BR>NPY-like immunoreactive (-LI) nerve fibers which are also immunoreactive for tyrosine hydroxylase (TH) were detected only around the vessels in the lobular area. However, TH-LI nerve nerve fibers were abundant around the acinar cells and ducts, as well as just around the vessels. In the hilus region TH-LI nerve fibers were obseved in large vessels, ducts, nerve bundles and submandibular ganglia were seen. NPY-LI nerve fibers were also detected around the vessels in the hilus region. Nerve bundles immunoreactive for NPY but not for TH were detected in the hilus region. In the superior cervical ganglion (SCG), many cells showed the coexistence of TH with NPY.<BR>Ten days after SCG extirpation, almost all of the NPY/TH-LI nerve fibers had disappeared; however, a few NPY-LI nerve fibers remained. The remaining NPY-LI fibers did not exhibit TH immunoreactivity. In the submandibular ganglia, NPY-LI- cells were detected. Some of these NPYLI cells also showed TH activities. Furthermore, all of the ganglion cells showed AchE activities.<BR>These results suggest that in the rat submandibular gland most NPY-LI nerve fibers exhibiting TH activities are sympathetic and adrenergic originating from the SCG. A few NPY-LI nerve fibers which remained after SCG extirpation and lacked TH-LI were parasympathetic and cholinergic originating from the submandibular ganglion cells.
- 特定非営利活動法人 日本口腔科学会の論文
特定非営利活動法人 日本口腔科学会 | 論文
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