Correlation of shedding herpes simplex virus type 1 into saliva and the occurrence of herpetic lesion in healthy human and hospitalized patients.

概要

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The correlation of the shedding of herpes simplx virus type 1 (HSV-1) into saliva and the occurrence of herpetic lesion were studied in 55 healthy individuals and 125 hospitalized patients with antibody to HSV-1. The hospitalized patients consisted of 101 oral surgery patients (34-undergoing oral surgery, 19 oral cancer, and 48 orofacial fracture) and 24-immunocompromised patients in the 1-st inner medicine. Specimens were collected regularly for about 2 months from each individual. HSV-1 was isolated 10.9% of the healthy individuals, 41.6% of the patients undergoing oral surgery and 54.2% of the immunocompromised patients. The frequency of hospitalized patients was obviously higher than that of healthy individuals. The frequencies of herpetic lesion in the healthy individuals, undergoing oral surgery, oral cancer, orofacial fracture and immunocompromised patients were 16.7%, 15.4%, 9.1%, 22.2% and 38.5% respectively. The occurrence of virus lesions of hospitalized patients was not different from that of the healthy individuals, except for immunocompromised patients. In the relationship of the occurrence of lesion and the time of the shedding of HSV-1 into saliva, in 5 cases HSV-1 was shed before the lesion occurred, in 4 cases shed just as occurred, and 1 case shed virus after the lesion occured. These suggest that HSV-1 is already beginning to reactivate before the herpetic occurred.
特定非営利活動法人日本口腔科学会の論文