A study on relations between osteoinfiltration and arachidonic acid metabolites in oral cancer.
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概要
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Some prostaglandins are known to accelerate tumor growth by means of weakening the immunity of the host but others are known to suppress the tumor. In oral cancer cases, tumor-infiltration into the bone is an important factor in progress and therapy of the cancer because oral mucosa is close to bones such as mandible and maxilla. Not enough reserch has been done with regard to relation between arachidonic metabolites and tumorinfiltration into the bone.<BR>In this research paper we analyse 10 oral cancer tissues and 5 tumor-infiltrated bones to find what metabolites accelerate or suppress tumor growth and what metabolites accelerate tumor-infiltration into the bone or osteo-absorpsion. W e use high performance liquid chromatography systems to analyse tumors, and infrared spectroscopic analysis systems with Fourier transformation for tumor-infiltrated bone, to get some knowledge as below. Possibly tissue γ-GTP has metabolized them before experiment, so LTC<SUB>4</SUB> and E<SUB>4</SUB> are seldom calculated. 15-HETE and PGD<SUB>2</SUB> tend to highly calculated in metastatic or low differentiated carcinoma. In IR spectrum of tumor-infiltrated bone, peaks ν<SUB>4</SUB> and ν'<SUB>4</SUB> are flattened, which reflect osteoabsorption, and the difference between spectrum of tumor-infiltrated bone and that of contrasted normal bone shows 1719 cm<SUP>-1</SUP> peak and 975 cm<SUP>-1</SUP> peak. The former may reflect PGA<SUB>1</SUB>, and the latter PGB<SUB>1</SUB> ejects or PGD. As the tumor which the most remarkable osteoabsorption contains much 6-keto PGF<SUB>1α</SUB>, PGI<SUB>2</SUB> may be one of the elements of osteo-absorption produced in cancer.
- 特定非営利活動法人 日本口腔科学会の論文
特定非営利活動法人 日本口腔科学会 | 論文
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