Relationship betweem long-term consective administration of OK-432 for oral cancer and Su-palysaccharide(Su-PS) skin test.

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We performed immunochemotherapy mainly by long-term consecutive administration of OK-432, a non-specific immunopotentiator, as adjuvant therapy in cases of oral cancer. We used the Su-PS skin test, an extremely simple method for routine clinical practice, as an immunological parameter. Changes in the Su-PS skin test value and peripheral lymphocytes were investigated in 22 cases administered OK-432 for at least 2 years. The Su-PS skin test values before OK-432 administration were compared in cases with good and with poor prognosis. The Su-PS skin test values, PHA reaction values and NK activity were also compared in cases administered and not administered OK-432. The following results were obtained.<BR>1) Su-PS values increased significantly during frequent OK-432 administration (5 KE, once a week) when compared with before administration, but there was no increase during intermittent administration (5 KE, once every 2 weeks to one month). There were no significant differences in changes in peripheral lymphocytes.<BR>2) Su-PS values before OK-432 administration were clearly lower in cases with poor prognosis than in those with good prognosis.<BR>3) In a comparison between the OK-432 frequent administration group and non-administration group, Su-PS and PHA values increased significantly, and NK activity tended to in crease in the former group.
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