Localization of subunit a of factor XIII in the oral and maxillofacial lesions - An immunohistochemical study.:An immunohistochemical study

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The localization of subunit A of blood coagulation factor XIII (FXIIIa) was investigated by the avidin-biotin-peroxidase complex (ABC) method in various oral and maxillofacial tissues comprising normal oral mucosa, normal submandibular gland, dilantin gingival hyperplasia (2 cases), epulis granulomatosa (3 cases), epulis fibrosa (4 cases), squamous cell carcinoma (7 cases), chronic sclerosing submandibular adenitis (3 cases), and fibrous dysplasia of the mandibular bone (1 case). The distribution of collagenous components was also examined in the same tissues by the method employing Sirius red F3BA.<BR>By the ABC method, certain connective tissue cells exhibited a cytoplasmic positive reaction for FXIIIa in each tissue examined. These FXIIIa-positive interstitial cells were few in number and spindle-shaped in the normal tissues as well as in the edematous lesions. As the lesions became more fibrous, however, these cells increased markedly in number and became dendritic and stellated in shape. In the scar-like lesions, they decreased slightly and became slender and spindle-shaped.<BR>The results obtained in this study indicate the close relationship between the distribution of FXIIIa-positive cells and that of collagenous components. This relationship seems to suggest the contributive role of FXIIIa-positive cells in the proliferation of collagenous fibers in the oral and maxillofacial lesions.
特定非営利活動法人日本口腔科学会の論文