Distribution of subunit a of blood coagulation factor XIII in radicular cyst. An immunohistochemical study.:An immunohistochemical study

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The distribution of subunit A of blood coagulation factor XIII (FXIIIa) and that of collagenous components were examined by the avidin-biotin-peroxidase complex (ABC) method for FXIIIa and by the method employing Sirius red F3BA, respectively, in 32 cases of radicular cysts.<BR>Aside from the covering epithelial layer, the radicular cyst wall was composed of the following three layers: an inner granulomatous layer, an outer fibrous connective tissue layer, and an intermediate layer. In every layer, positive reaction for FXIIIa was observed in certain connective tissue cells. These FXIIIa-positive cells were sparse in the inner granulomatous layer, while they were numerous in the outer fibrous connective tissue layer. Also in the intermediate layer, many more FXIIIa-positive cells were observed, and most of them were dendritic in shape, in contrast to the cells in the outer fibrous connective tissue layer, which were slender and spindle-shaped.<BR>The results obtained in the present study indicate the close relationship between the distributions of FXIIIa-positive cells and of collagenous components. Such a relationship suggests that FXIIIa-positive cells play an important role in the process of fibrosis occurring in the radicular cyst wall.
特定非営利活動法人日本口腔科学会の論文