Appearance of Antibacterial Activity of Oxacillin against Methicillin Resistant Staphylococcus aureus(MRSA) in the Presence of Catechin.
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概要
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We previously reported that tea catechin shows bactericidal activity against various bacteria including methicillin resistant <I>Staphylococcus aureus</I> (MRSA) and that bactericidal catechin damages the lipid bilayer of bacterial cell membranes. Here we describe that oxacillin (MPIPC) shows antibacterial activity against MRSA in the presence of catechin below MIC.<BR>Twenty clinical isolates of MRSA were examined by a cup method. In the absence of catechin, MPIPC even at a concentration of 40, μg/ml did not show antibacterial activity against all isolates of MRSA. However, when catechin below MIC (25-100, μg/ml) was mixed with the agar medium, MPIPC (5-12.5, μg/ml) showed antibacterial activity against all MRSA isolates. By counting the numbers of viable bacteria in a broth culture, only MPIPC (5, μg/ml) or catechin (100, μg/ml) showed similar growth curves to the control. But addition of both MPIPC and catechin reduced the number of viable bacteria to 1/100-1/10000 after 24 hours of cultures.<BR>Besides MPIPC, in the presence of catechin below MIC methicillin (12.5, μg/ml), aminobenzylpenicillin (32 μg/ml), tetracycline (2.5 μg/ml), and chloramphenicol (12.5μg/ml) showed antibacterial activities against multiple drug resistant MRSA to antibiotics mentioned above.<BR>These findings suggest a possible use of catechin in the treatment of MRSA infection.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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