Studies on the host factors in the outbreak of odontogenic infection. The background factors of patients and the effect of serum after sleep deprivation on PMN chemotaxis.:The Background Factors of Patients and the Effect of Serum after Sleep Deprivation
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These studies were carried out to investigate the background factors in the outbreak of acute infection of odontogenic origin.<BR>In the clinical study, fifty patients who suffered from acute odontogenic infection were compared with fifty symptom free controls with chronic odontogenic inflammation. The subjects were asked whether they had basal disease or not, and were given a series of questionnaries about the episodes of recent life changes (f.e. busy, decrease of sleeping time, travel etc) to measure the incidence of these background factors.<BR>In the experimental study, the effect of serum after 24 hours sleep deprivation on PMN chemotaxis in vitro was studied in six young voluunteers. Chemotactic assays were performed with the modified Boyden chamber method.<BR>Results obtained were as follows:<BR>1) The basal diseases were observed in 16 cases (32%) with acute odontogenic infection, and in 14 cases (28%) of controls. The incidence was not different statistically between both groups.<BR>2) The incidence of background episodes in the patients were noted in 39 cases (78%) of patientsand 10 cases (20%) of the controls (p<0.01). The predominant factor in these episodes were busy (36%), and decrease of sleeping time (30%) in the patient group.<BR>3) Serum of all 6 subjects obtained after sleep deprivation showed depressed effects on PMN chemotaxis to chemotactic factor. (p<0.05).<BR>4) Pre-exposure levels were regained in five of the six subjects within seven days after terminating the visil.<BR>These results suggest that fatigue plays a major role in the susceptibility to acute odontogenic infection by the alternation of PMN chemotaxis. Further studies would be necessary on chemotactic factors in the serum and other functions in order to appreciate the host-parasite interaction in acute odontogenic infections.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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